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KMID : 0616120070380030287
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 3 p.287 ~ p.290
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Cytoprotective Constituents of the Stem Barks of Fraxinus rhynchophylla on Mouse Hippocampal HT22 Cells and Their Antioxidative Activity
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Jeong Gil-Saeng
Yoon Kwon-Ha
Kim Youn-Chul
Kang Dae-Gil
Lee Ho-Sub
Kim Hyun-Chul
Oh Seung-Hwan
Kim Myong-Jung
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Abstract
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Phytochemical investigation of the MeOH extract of the dried stem barks of Fraxinus rhynchophylla Hance (Oleaceae), as guided by cytoprotective activity against tert-butyl hydroperoxide (t-BHP)-induced cell injury in mouse hippocampal HT22 cells, furnished two coumarins, esculetin (1) and fraxetin (2). Compounds 1 and 2 had the significant cytoprotective effects on t-BHP-induced cellular oxidative injury in HT22 cells. Furthermore, compounds 1 and 2 showed potent DPPH radical scavenging effect, exhibiting IC50 values of 14.68 and 9.64 μM, respectively.
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KEYWORD
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Fraxinus rhynchophylla, HT22, t-butyl hydroperoxide, cytoprotective effect, DPPH radical scavenging
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